Information for Primary Care Physicians

Why consider a minimally invasive procedure to treat enlarged prostate, early on?

Quality of life and overall health are important considerations in treating BPH. Watchful waiting can risk bladder health. Medications can cause bothersome side effects and often fail to provide significant symptom relief.

Watchful Waiting Comes with Risks

• Bladder outlet obstruction may result in irreversible bladder damage if left untreated.^{14, 15}.
• 87% of men who elect watchful waiting experience a worsening of symptoms over a four year time period. ¹⁶
• Men who delay TURP with watchful waiting have significantly worse outcomes than those who had TURP sooner. ¹⁷

Patients on BPH Medications Are Not Satisfied

• 48% of patients on medications do not have a clinically significant improvement in symptoms (< 4 point IPSS improvement)⁸.
• 5ARI drugs take three to six months for symptom relief.^{9, 10}
• Side-effects include headaches, dizziness, asthenia, nasal congestion, loss of libido, ejaculatory dysfunction, erectile dysfunction.²

Preservation of Sexual Function is Important to BPH Patients

• In a global survey of over 13,000 men age 40-80 across 29 countries, nearly 50% rated sex as being very to extremely important.¹⁸.
• Erectile dysfunction contributes to anxiety, depression, loss of self-esteem and diminished quality of life. ¹⁹

Surgery is a Big Step for Patients

• Surgery with general anesthesia comes with operative risks: transfusion, significant hematuria. ².
• Catheterization for days.⁵
• Four to six weeks irritative voiding symptoms and recovery.³
• Risk of permanent complications: Urinary incontinence, Sexual dysfunction, Urethral stricture. ²

Who is a candidate?

Men with BPH:

• Hoping for increased symptom relief
• Wanting off of BPH medications and to preserve sexual function
• Looking for a less invasive solution
• Who are concerned about surgery

TURP or Laser Candidates:

• Concerned about complications
• Wanting to preserve sexual function
• Wanting a more rapid return to daily life
• With a prostate volume of up to 100cc

Patient Information Brochure

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Post-Treatment Expectations

• Symptom improvement may start within 2 weeks and continue to improve for up to 3 months.¹
• Most common side effects are temporary and can include discomfort when urinating, urgency, inability to control the urge, pelvic pain, and some blood in the urine.
• Rare side effects include bleeding and infection, may lead to a serious outcome, and may require intervention.
• Most symptoms were mild to moderate in severity and resolved within two to four week after the procedure.¹
• Durability proven out to 5 years.¹

See full safety statement at UroLift.com/Patient-Safety.

Physician Information Brochure

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Faster Recovery. Fewer Risks. Proven Outcomes.

Compared to medications, the UroLift System has demonstrated a much more positive effect on quality of life for patients.¹ The UroLift System treatment preserves sexual function and avoids complications typically associated with other BPH procedures.^1,2

The UroLift System Treatment Delivers a Superior Patient Experience

• Rapid relief and recovery^3,4
• Lowest catheter rate of the leading BPH procedures^3,5
• No new, sustained erectile or ejaculatory dysfunction^1,3,4
• Proven durability through five years¹

Five Year Data Demonstrates That Outcomes Are Rapid, Durable and Reproducible

IPSS Improvement

Improvement in LUTS, as seen through average reduction in IPSS (International Prostate Symptom Score), has been consistent across the various studies, showing rapid relief within two weeks and sustained effect through five years.¹ IPSS improvement at one year is better than seen with medications.^2,4

Quality of Life Improvement

Quality of life also improved significantly, with the IPSS QOL and BPH Impact Index maintaining 50% and 52% improvements, respectively at five years, p<0.0001.¹

Flow Rate Improvement

In addition to improving LUTS, the UroLift System treatment has demonstrated significant average improvement in peak urinary flow rate (Qmax) of 3.5 mL/sec (44%) that was sustained to five years, p<0.0001. ¹

Low Retreatment Rate

The rate of surgical intervention for failure to cure with the UroLift System remains low for a BPH procedure, with approximately 13.6% over five years or about 2-3% per year.¹ Over the first postoperative year, no additional surgical intervention was required for bladder neck contracture, bleeding, or stress incontinence in the pivotal study on UroLift System.⁴

Preservation of Sexual Function

^{The UroLift System treatment is the only leading BPH procedure shown not to cause new and lasting sexual dysfunction* 2,4,21 UPDATE REFERENCES AT BOTTOM}